![]() The gene expression profile of GSE29859, including 4 cortical bone marrow samples with excessive doses of Vitamin A and 4 control cortical bone marrow samples, was obtained from the Gene Expression Omnibus (GEO) database. The aim was to research the molecular changes of bone cells induced by excessive dose of vitamin A, and analyze molecular mechanism underlying spontaneous fracture. Peng, Chuangang Yang, Qi Wei, Bo Liu, Yong Li, Yuxiang Gu, Dawei Yin, Guochao Wang, Bo Xu, Dehui Zhang, Xuebing Kong, Daliang ![]() Identification of potential target genes and related regulatory transcription factors in spontaneous hairline fracture induced by hypervitaminosis A. In addition to Tr1 and thymic CD4+CD25+ T cells, peripheral Ti-Treg cells emerge as a class of regulatory T cells with therapeutic potential in T cell mediated chronic intestinal inflammation. Our data suggest that regulatory Ti-Treg cells expand by TGF-beta and exogenous IL-2 derived from effector T cells at the site of inflammation. Further analysis of in vivo and in vitro expanded Ti-Treg cells showed that exogenous interleukin 2 (IL-2) was crucial for survival and expansion of these cells. Ti-Treg cells significantly suppressed Th1 mediated colitis on CD4+CD62L+ T cell transfer in vivo, as shown by high resolution endoscopy, histology, immunohistochemistry, and cytokine analysis. Ti-Treg cells were generated in cell culture in the presence or absence of TGF-beta and tested for their regulatory potential in experimental colitis using the CD4+CD62L+ T cell transfer model. Here, we analysed the in vivo function of TGF-beta induced regulatory T (Ti-Treg) cells in experimental colitis. In addition to the thymus, CD4+CD25+ regulatory T cells can be induced in the periphery from a population of CD25- T cells by treatment with transforming growth factor beta (TGF-beta). The imbalance between effector and regulatory T cells plays a central role in the pathogenesis of inflammatory bowel diseases. Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.įantini, M C Becker, C Tubbe, I Nikolaev, A Lehr, H A Galle, P Neurath, M F Our results show that RSV infection induces expression and catalytic activity of IKK induction, indicating that ROS generation plays a fundamental role in the signaling pathway leading to IRF-3 activation, therefore, identifying a novel molecular target for the development of strategies aimed to modify the inflammatory response associated with RSV infection of the lung.« less In this study, we have investigated the signaling pathway leading to RSV- induced IRF-3 activation and whether it is mediated by intracellular reactive oxygen species (ROS) generation. Respiratory syncytial virus (RSV)- induced chemokine gene expression occurs through the activation of a subset of transcription factors, including Interferon Regulatory Factor (IRF)-3. Ikkepsilon regulates viral- induced interferon regulatory factor-3 activation via a redox-sensitive pathway
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |